B6 (Vitamin B6) is also called Pyridoxine
That includes pyridoxine, pyridoxal and pyridoxamine phosphate in vivo, exists in the form of a Water soluble vitamins
In case of light or alkali, easy damage, high temperature. In 1936 named Vitamin
B6 is a colorless crystal, soluble in water and ethanol
, the acid in the stable, easy to damage, the lye pyridoxine heat, pyridoxal and pyridoxamine are not resistant to high temperature. Vitamin
More content in yeast, liver, Gu Li, meat, fish and eggs, beans and peanuts in B6. Vitamin
B6 is the body of some coenzyme
The components involved in a variety of metabolic reactions, and especially Amino acid metabolism
There is a close relationship between. Clinical application Vitamin
B6 preparation for prevention of nausea and vomiting of pregnancy and radiation sickness and vomiting.
Vitamin B6 Drug information
[ Chemical property
] containing pyridoxine or pyridoxal or pyridoxamine group B Vitamin
. The acid in the stable, easy to damage, the lye pyridoxine heat, pyridoxal and pyridoxamine are not resistant to high temperature.
[ Physical property
B6 is a colorless crystal, soluble in water and ethanol
[ Molecular formula
"1] C8H11NO3 HCl" Chinese Pharmacopoeia
[ Molecular formula
2] commonly used Molecular formula
[ Molecular formula
Pyridoxine C8H11NO3 3]
[ Molecular formula
Pyridoxal 4] C8H9NO3
[molecular formula 5] C8H12N2O2 pridoxamine
Vitamin B6 The requirements of Chinese Pharmacopoeia
This product is 6- -5- -3,4 two hydroxy methyl pyridine methanol hydrochloric acid
According to the measurement of crystal salt, drying, containing C8H11NO3 - HCl should be 98.0%-102.0% Character
This product is white crystal or white crystalline powder, odorless, bitter taste, light quality gradient. Soluble in water, in ethanol
Slightly soluble, insoluble in chloroform or ether.
The acidity of
product 1.0g, 20ml water to dissolve, the measured PH should be 2.40-3.00.
The dry weight loss
products, under the condition of 105 DEG C dried to constant weight, lose weight not more than 0.5% Burning residue
shall not exceed 0.1% The heavy metal
shall not exceed 10ppm
Vitamin B6 find
In nineteenth Century, pellagra (pellagra) in addition to being found nicotinic acid deficiency, in 1926 they found another Vitamin
Lacking in feed, can also cause mice induced pellagra, then this substance in 1934 was named vitamin B6, until 1938~1939 was isolated, and qualitative and able to synthesize vitamin B6.
Vitamin B6 chemical composition
B6 refers to the ratio of known substances for the duo, containing vitamin B6 active substances is pyroxidine (pyridoxine), but this function has three kinds of chemical forms:
his Molecular formula
Were pyridoxine (C8H11NO3), 2 (C8H9NO3), the pyridoxal pyridoxamine (C8H12N2O2).
Frequently-used Molecular formula
This substance is soluble in water and colorless alcohol
The crystal, because of containing salt (NaCl) ingredients, so with a little salty taste. This kind of material is not sensitive to heat, but encountered alkaline substances or ultraviolet light of the class, would soon break down. hydrochloric acid
About 204 DEG ~206 DEG pyroxidine melting point.
Vitamin B6 Food sources
Vitamin B6 powder
Food sources of vitamin B6 is very extensive, animal and plant foods contain. Usually meat, whole grain products (especially wheat), high content of vegetables and nuts. Animal food sources of vitamin B6 in the bioavailability of source plants better than food. In animal and plant food were the most micro, yeast powder, rice bran or rice were also many, followed from the meat, poultry, fish, potatoes, sweet potatoes, vegetables.
A variety of foods containing edible part of every 100g Vitamin
The amount of B6 as follows: 3.67mg 2.91mg yeast powder, defatted rice bran, rice 2.79mg, linseed meal 1.25mg, custard 0.8 ~ 0.04mg, carrot 0.7mg, fish 0.45mg, whole wheat extract meat 0.4 ~ 0.7mg, 0.3 ~ 0.08mg, 0.3 ~ 0.03mg 0.25mg egg milk, Spinach
Sweet potato 0.22mg, 0.14 ~ 0.23mg, pea 0.16mg, 0.1mg soybean, orange 0.05mg.
Vitamin B6 Drug instructions
Tablet: each tablet 10mg. Injection; each 25mg (1ml); 50mg (1ml); 100mg (2ml).
Cream: each containing 12mg. Vitamin
B6 sustained-release tablet: each tablet 50mg. A 50mg, 1 to 2 times a day. Compound vitamin B tablets
Each tablet contains: B13mg, B21.5mg, B60.2mg, nicotinamide
10mg. Take 1 to 2 tablets each time, 3 times a day 1. Compound vitamin B injection
: each containing B120mg, B22mg, B62mg, nicotinamide
30mg (2ml). Each injection 2ml, 1 times a day.
Vitamin B6 pharmaceutical analysis
The name of the method: Vitamin
The determination of B6- High performance liquid chromatography
The scope of application:
The method uses High performance liquid chromatography
The content of B6 (C8H10NO5P).
This method is applicable to Vitamin
The sample is made into the mobile phase solution. High performance liquid chromatography
The chromatographic separation was performed by Ultraviolet absorption detector
In the detection wavelength of 291nm. Vitamin
B6 absorption value, calculated its content.
2 0.04% sodium pentanesulfonate solution (with ice acetic acid
Adjust the pH value to 3)
Three Acetic acid
Instrument and equipment:
One point one High performance liquid chromatography
The 1.2 column
Eighteen alkyl silane bonded silica as filler, according to the number of theoretical plates Vitamin
The peak of B6 calculation is not less than 4000.
One point three Ultraviolet absorption detector
2 chromatographic conditions
2.1 mobile phase: 0.04% sodium pentanesulfonate solution of methanol =85 15.
2.2 detection wavelength: 291nm
The 2.3 column temperature: room temperature
1 weigh sample
Take proper amount of the product precision.
2 standard solution preparation
Precision weighing Vitamin
B6 control amount of goods, with the sample preparation, shake, namely.
3 for sample preparation
Commodities will be tested with mobile phase is dissolved and diluted into quantitative solution, each containing about 1mL 0.1mg shake, namely.
Note: the "precision" of alleged take weight should be accurate to take the weight of 1/1000. "The precise amount" means the amount of volume accuracy should comply with national standards on the volume pipettes accuracy requirements.
Then precisely absorbing the control solution and sample solution 10 L injection High performance liquid chromatography
Use. Ultraviolet absorption detector
To determine the wavelength of 291nm. Vitamin
B6 absorption value and calculate its content.
Reference： Pharmacopoeia of People's Republic of China
The State Pharmacopoeia Committee, Chemical Industry Press
, 2005 edition, two, p.668.
Vitamin B6 Requirement
Vitamin B6 deficiency symptoms after
In general, human and animal gut micro-organisms ( Bacteria
), synthesis Vitamin
B6, but little volume, or from a food supplement. The amount of fact and Protein
There is a relationship between the feeding amount, if eat meat and fish, should remember to add a large number of Vitamin
B6, in order to avoid vitamin B6 deficiency caused chronic disease
The occurrence of.
Male adult 2.0mg
1.0~1.4mg under 11 years old.
Boys and girls 1.4~2.0mg
The maximum capacity of 4-50mg, toxic dose of the unknown.
Vitamin B6 Metabolic changes
Vitamin B6 Digestion and absorption
The catabolism of tryptophan
In food Vitamin
B6 PLP, PMP, PN by nonspecific phosphorylase in the intestinal lumen (nospecific phosphoh Ydrolase), PMP decomposition of PLP PL, PM. The form PL, PM absorption and PN. In the observation of human body, the hungry given by PN, PL, PM, PN in 0.5 ~ 3H after peak, small dose (0.5 ~ 4mg), plasma Vitamin
The level of B6 in 3 ~ 5h and then return to approximate hunger level. After taking PL plasma Vitamin
The level of B6 and PA in urine increased rapidly, but the PM absorption and metabolism than PN, PL is slower. The intake of PLP high dose (10mg), plasma Vitamin
B6 and PLP continue to rise in 24h, maintained at a high level.
Vitamin B6 Transport and metabolism
PN transport to the intestinal mucosa and into the bloodstream, can also synthesize PNP in the intestinal mucosa, approximately 30.6% PN dose, blood spread to the muscle, then phosphoric acid
Of about 10.4% doses to 15.7%. In the human body by PN, plasma PL can increase 12 times, although the proportion of plasma PLP in plasma Vitamin
B6 60%, but combined with the protein, is not easy for the other Cells
The use of. Plasma PL and albumin binding is not strong, as the form of transportation, can be tissue uptake and clearance, and oxidation of PA. PN and PL by diffusion into the Red blood cell
And, for the kinase phosphoric acid
Of. People Red blood cell
PNP can be oxidized PLP, other animal such as rats without this function. In more than PN Red blood cell
PL kinase saturation concentration
When, at 3 ~ 5min into red blood cells, cells concentration
With medium consistency. PL at the concentration of more than Red blood cell phosphoric acid
When the concentration of kinase, into the red blood cells increased, the concentration ratio of medium to high and this is due to PL hemoglobin
At the end of the combination of valine in the alpha chain, so the accumulation of PL in red blood cells, its concentration in red blood cells in plasma for 4 to 5 times. Red blood cell
The PL may also be a means of transport.
The liver is also Vitamin
Metabolically active tissue B6. PN for liver Cells
In, have PL kinase and PNP oxidase Effect
The generation of PLP, and then the solution and transformed into PL phosphorus, into the circulatory system, and transported to the phosphoric acid
The formation of PLP kinase organization.
No PN in brain slices and isolated choroid plexus, and phosphate are Chemical compound
For the transport of PN from the choroid plexus, blood cerebrospinal fluid to the place. stay Vitamin
B6 deficient animal (rat) PL kinase decreased, feed 5 weeks in rat liver, liver kinase PL dropped 50% while the brain decreased only 14%. This also shows that Vitamin
The importance of B6 on nervous system.
Vitamin B6 Storage Vitamin
B6 in the bloodstream can spread to the muscles and phosphoric acid
PN, if the dose increased, the muscle PN accounted for dose was increased, and the percentage of PNP decreased. No PNP to PLP oxidation in muscle. In 60% rats Vitamin
B6 in the muscle, which ranged from 75% to 95% with glycogen phosphoric acid
Enzyme linked (Glycogenphosphorylase). This enzyme for muscle soluble protein 5%, may Vitamin
B6 storage space. Through the conversion of the muscle protein will Vitamin
B6 decomposition to meet the minimum requirement.
Vitamin B6 discharge Vitamin
B6 the main metabolite of PA, which can represent the vitamin B6 intake amount of 20% ~ 40% PA in urine can only intake index. Not on behalf of the body and store. The urine in addition to PA, there is a small amount of PN and PL. To physiological doses, most of the PA discharge in 3h. In PN Renal tubule
The accumulation, when PN concentration
Large, can be excreted by the kidneys. The PN dose of 10mg, PA in urine accounted for the percentage of dose decreased, but PN increased discharge. PL is not easy to be renal elimination, is not easy to be incorporated into the kidney. phosphoric acid
The form of accumulation. But high dose (100mg) of PL, PM, PN, 36h in most of the original in the urine.
Vitamin B6 treat a complaint
Vitamin B6 General disease
1, 2, 3 bald arteriosclerosis, high cholesterol, 4 Cystitis
5, face greasy, 6 Hypoglycemia
In 7, 8 mental disorders, neurological disorders, muscle imbalance, 9 10 early pregnancy vomiting, 11 overweight, 12 postoperative vomiting, 13 urgent, 14 sun sensitive etc..
Vitamin B6 Diabetic vascular Vitamin
B6 can slow down Insulin
Treatment of vascular complications in diabetic rats, vascular disease
Complications are the main cause of death in diabetes mellitus. Arterial disease in insulin-dependent (Insulin-dependent diabetes, mellitus, IDDM) and non-insulin-dependent (NonInsulin-dependent diabetes mellitus, NIDDM) patients on the rate of prevalence is higher than average person. Diabetes vascular disease
The main complication is caused by atherosclerosis.
Vascular endothelial Cells
Injury (Endothelial injury) is known to cause arteriosclerosis. Thrombosis factor (Thrombogenic factors), including Platelet
Excessive activation (Hyperactive) or excessive platelet agglutination, the process will promote arteriosclerosis. Vitamin
Activation of type B6, phosphoric acid
Pyridoxal (Pyridoxal phosphate, PDP), has the protection of vascular endothelial Cells
And reduce the injury induced by activated platelets and endothelial cells, inhibiting platelet aggregation and blood coagulation function, inhibit platelet generation of prostacyclin (Thromboxane A2, TxA2) and promote vascular endothelial growth ring Prostaglandin
(Prostaglandin I2 PGI2) function, and reduce vascular endothelial cell morphological changes.
Vascular endothelial Cells
Damage is considered to be an early pathological phenomenon of atherosclerosis, such changes affect many functions of vascular endothelial cells, including permeability and adhesion, motion
Cell proliferation and material generated capabilities.
Vitamin B6 Physiological function
Effect of vitamin B6 on the brain
The B6 group will soon be transformed into Fumei pyridoxal phosphate and pyridoxamine phosphate, the two kinds of enzymes and Protein
The metabolism is closely related to pyridoxal, phosphate is the replacement of the following substances thabo:
The required amino transfer of amino acid metabolism, especially for methylthio amino, cystine, cysteine, etc..
The decarboxylation of amino acid metabolism (=COOH) requirements.
Conversion of sulfur amino acids required (methylthio amino, cystine, cysteine), homocysteine is a lack of Vitamin
B6, should pay attention to.
Methionine, homocyteine + serine (SER), pyruvate (coke Glucose
+ H2S + NH3), TCA cycle (energy + CO2 + H2O).
Methionine is methyl (methyl group) is an important amino acid, without Vitamin
B6, this effect can not be. A lot of carbonation effects shall not be carried out, such as synthesis of fat, amino acids and other carbon frame.
Related with tryptophan into niacin, tryptophan, nicotinic acid, if the lack of Vitamin
B6, which is the intermediate metabolite --- Xanthurenic acid
(xanthurenic acid), the substance in the body destroys pancreatic beta Cells
Finally, leading to the occurrence of diabetes. In clinic, the amount of xanthurenic acid in urine testing to determine whether or not Vitamin
B6 deficiency, if yellow too much uric acid levels, which means the risk of vitamin B6 deficiency.
Glycogen into glucose needed, there is Vitamin
The presence of B6, glycogen and phosphorylase can accelerate the decomposition of glycogen into glucose.
take fatty acid
Flax oleic acid
(linoleic acid--18C) into peanut oleic acid (arachidonic acid--22C) required, if the lack of this acid, it will cause skin cracking, and even for Cells
Membrane degeneration caused by physical discomfort.
Coenzyme -A (co-enzyme A) synthesis, if the lack of Vitamin
B6, the synthesis of coenzyme -Co-A block. The composition of coenzyme -Co-A Pantothenic acid
(adenine), is produced by the energy related substances, required for acetyl Co-A and acetyl Co-A reduction, direct synthesis of fat in the mitochondria inside and outside, acetyl Co-A is also involved in the biochemical effects of amino acid synthesis and energy production, is a very important material.
stay brain cell
The metabolism of coenzyme pyridoxine, decarboxylation of amino acids is very important, so a stable function of brain cells, not the lack of Vitamin
B6. What is more, the brain cells related to the synthesis of amine compounds, are needed Vitamin
B6. This kind of material such as adrenaline
(epinephrine), norepinephrine (norepinephrine), dopamine (dopamine), duo tyramine (tyramine), blood (serotonin-5 hydroxytryptamine) - amine. Where is the new adrenaline dopamine precursor substances, and blood amine hormone and synthesis of melatonin hormone
. These brain substances, also plays a role in brain cells Chromosome
The role of the transfer function.
Pyridoxine is not only the coenzyme containing amine compounds, but also is the spread of brain cell inhibitory substances (gama-amino butyric acid) GABA coenzyme required. Human deep sleep when the content of GABA will rise very high, showing Vitamin
To improve the GABA B6, to make it easier to sleep, deep sleep. So let the excitement of the brain cells to rest, except for melatonin
Also, add Vitamin
B6 to play a good function.
The B6 function increases the nutrients
If there are some nutrients exist, will increase Vitamin
The function of B6, such as 1 Vitamin B group
2, vitamin B1, vitamin B2 3, vitamin C, pantothenic acid, 4 5 mg, 6 K, 7 sodium, 8 linoleic acid (linoleic acid).
Effect of antagonistic substances and - Vitamin
B6 demand situation
1 alcohol, 2 contraception
3 pills, tobacco, coffee, 4 5 radiation.
B6 deficiency symptoms Vitamin
The main function of B6 in human body blood
Muscle, nerve, skin, etc.. Function antibody
The synthesis, digestive system, and fatty acid production Protein
Use (especially in the diet should be added), maintaining the balance of sodium / potassium (stable nervous system). Lack Vitamin
Pass in the B6, there will be a general lack of appetite and food utilization rate is low, weight loss, vomiting, diarrhea and other illnesses. There will be a serious lack of acne, anemia
And children spasm
, depression, headaches, hair loss, easy, Learning disorder
Large dose toxicity
With a high dose of 300mg per day for the prevention and treatment of nausea and vomiting after exposure to radiation, medicine and vomiting after anesthesia vomiting, travel sick and vomiting, can achieve therapeutic effect, and no toxicity.
Vitamin B6 The need for nutrition Vitamin
B6 is the essential substance of fat and carbohydrate metabolism of the human body, female estrogen
Metabolism also need vitamin B6, so it is good for the prevention and treatment of some gynecological diseases. Many women taking the pill for lead to pessimistic, irritable, self fatigue, 60 mg daily supplement can relieve symptoms. Some women suffer from premenstrual Tension syndrome
That is menstruation
Hand and foot edema, insomnia, forgetfulness, eat 50 ~ 100 mg Vitamin
After complete remission of symptoms can be b6. B6 rich food, thin tuna steak, Chicken
Meat, bananas, peanuts, beef etc..
Vitamin B6 physiological function
Mainly phosphoric acid
Pyridoxal (PLP) in the form of nearly 100 kinds of enzyme reaction. Most related to amino acid metabolism: including transamination and decarboxylation, side chain cleavage, dehydration and turn vulcanization. These biochemical function involves many aspects.
1, participate in Protein
Synthesis and catabolism of amino acid metabolism, the participation of all, such as heme metabolism, associated with the synthesis of nicotinic acid tryptophan.
2, gluconeogenesis and UFA metabolism. With glycogen, nerve sheath phospholipid
And steroid metabolism.
3, to participate in some neurotransmitters (serotonin 5-, taurine, dopamine, noradrenaline and GABA) synthesis.
B6 and one carbon unit, Vitamin B12
and folic acid
Salt metabolism, metabolic disorder if they can cause Megaloblastic anemia
5, involved in nucleic acid synthesis and DNA synthesis, the lack of damage to DNA, this process is very important to maintain proper immune function.
The relationship between B6 and vitamin B2 lack of vitamin B6 is very close, often accompanied by symptoms of vitamin B2.
7, to participate in homocysteine methionine
The transformation has decreased chronic disease
The role of mild Hyperhomocysteinemia
Is considered vascular disease
A possible risk factor, Vitamin
B6 intervention can reduce the hcy
Vitamin B6 New clinical application
With the in-depth study of clinical application, found Vitamin
B6 in clinical has a wide range of new uses, are as follows
1 rescue isoniazid poisoning
For each 1g service usage isoniazid
Can slow intravenous injection Vitamin
B61g. If I do not know Toxic dose
But, slow intravenous injection Vitamin
B65g, which lasted for 3 ~ 5min, 5 ~ 20min interval can be poor until the repeated injection of seizures, recovery of consciousness so far. Vitamin
The amount of B6 deficiency is the main reason of failure to rescue.
Two Treatment anemia Vitamin
B6 coenzyme delta aminolevulinic synthetase, this enzyme is the rate limiting enzyme in the synthesis of hemoglobin, so it can be used to prevent anemia
Three Treatment white blood cell Reduce disease Vitamin
B6 is involved in amino acid and fatty acid metabolism, stimulate white Cells
Generation, and can be used in the treatment of leukopenia. Usually a daily dose of 30 ~ 60mg, also available Vitamin
B650 ~ 100mg into 20ml 5% glucose intravenous injection.
4 treatment of mental retardation
One of the cause of this disease is the gene mutation of DNA molecule, the arrangement of amino acids, the genetic information transmission impairment caused by defects or reduced enzyme activity, leading to a variety of metabolic disorders. Vitamin
Metabolism and metabolic enzyme B6 can participate in amino acids, with correct all kinds of abnormal metabolism function. According to clinical observation, mental retardation, taking Vitamin
B6 every 1 months for 1 course of treatment, after 1 weeks of rest for second courses, second to 4 months after treatment, can improve the intelligence.
Five Treatment Mouth ulcer Vitamin
B6100mg/, 3 /d 100mg joined the oral or intravenous injection of 5%GS20ml, generally 3 to 4 days or more.
6 treatment Arteriosclerosis
B6 can promote linoleic acid
Into four arachidonic acid, and the latter Cholesterol
With synthetic ester and easy transport metabolism and excretion. In addition, Vitamin
The formation of B 6 can inhibit the function of platelet and fibrin, which can reduce cholesterol and prevent Thrombosis
. For the usage of the 50mg/d injection.
From the birth of the 2 ~ 6 day, after 5 to 6 days, 0.2g/ times, 3 /d orally, 10 ~ 12h effect, the inhibition of milk secretion rate reached 95%, than estrogen
Quick, good effect and no side effects. With the promotion of brain function principle dopamine
The generation, so as to reduce stimulation of dopamine receptors The pituitary Prolactin
Eight Treatment Parkinson Syndrome
The tremor was significantly reduced, began after the intramuscular injection of 50mg/d, increased gradually until 50mg/d, 0.3 ~ 0.4g/d, 12 ~ 15 days for a course, a total of 3 ~ 4G. The role of dopamine in the brain and improve the principle concentration
Thus, excited striatal dopamine receptors.
Nine Treatment Tetanus
Tetanus toxin can inhibit Gamma aminobutyric acid
The release of spasm, Vitamin
B 6 can promote the synthesis of gamma aminobutyric acid and anti convulsion, and Penicillin
The combination of +TAT, spasm control early, the death rate was 15%, while the TAT+ of penicillin + sedative mortality rate as high as 60%. For usage Vitamin
B 6120mg/d, 2 oral or intramuscular injection of 100mg/d.
Ten Treatment Gestational diabetes mellitus
Pregnant women lack Vitamin
B 6 induced tryptophan metabolism, insulin produced xanthurenic acid complexes, halving the hypoglycemic effect of the latter is caused by Gestational diabetes mellitus
. Vitamin B 6100mg/d * 2 weeks of treatment, the blood glucose decreased significantly, and the glucose tolerance curve change.
Eleven Steroidal contraceptives caused by The spirit of depression
Estrogenic effects in oral contraceptives can reduce phosphoric acid
And, to increase the body Vitamin
Requirement for B6 change brain amine metabolism, so it is easy to cause mental disease suppression. give Vitamin
After B 6, can improve the symptoms of depression.
12, enhance immunity and anticancer Vitamin
B 6 the lack of damage Cells
And the effect of humoral immune function, vitamin B6 can enhance immunity, and have anti-cancer effect, which may be related to a decrease in the carcinogen.
Thirteen Treatment Vitamin By C oxalate Salt stones Vitamin C
And then metabolized to oxalic acid, Ca 2+, Mg 2+ formation of oxalate stones, so the daily dose of vitamin C1g, vitamin B should add 650 ~ 100mg against stone, because urethral calculi of vitamin B6 on the major component of the effective oxalate.
Fourteen Vitamin B 6 dependent convulsion
This disease is an autosomal recessive genetic disease, because Vitamin
B 6 with protein enzyme glutamate
According to glutamic acid decarboxylase, and reduce the production of GABA, causing convulsions. According to clinical observation, seizure, intravenous injection Vitamin
B6100mg/, a few minutes after the attack to stop.
15 antiasthmatic effect
Infant wheezing respiratory disease is common symptoms, asthma treatment is key and difficult. According to the clinical observation of 120 cases of asthmatic children by time Intravenous injection Vitamin
B615 ~ 20mg/kg, 2 ~ 3 times a day, 4 days for a course of treatment, the total efficiency of 84%. The mechanism may be as follows: dopamine decarboxylase catalysis Tyrosine
Synthesis of epinephrine, the enzyme is Vitamin
B6 dependent enzymes, vitamin B6 deficiency reduced the synthesis of epinephrine, easy bronchial spasm. The part of blood, sputum in children with asthma 5- HT concentration
May exist in the body and increased. Vitamin
The 6 B amino acid metabolism disorders, with large doses of vitamin B6 after treatment, TLT returned to normal, asthma improvement.
Sixteen Treatment Carpal tunnel syndrome
This disease and Vitamin
B6 deficiency. According to clinical observation, patients taking daily Vitamin
B6300mg, for 4 weeks, usually after 2 weeks of treatment, the symptoms can be relieved completely.